In honor of World AIDS Day, the Killers released their fourth annual holiday single, “¡Happy Birthday Guadalupe!”, through the (RED) campaign today. All proceeds from the charity tune go toward the Global Fund to fight AIDS in Africa. The Las Vegas-based band also get a little back up from Wild Light and Mariachi El Bronx on the track.

Meanwhile, the video packs a bit of a surprise, as former Beverly Hills, 90210 heartthrob Luke Perry stars as a rugged cowboy in the music video for the Mexican-flavored Christmas tune. (And, geez—we knew Perry was playing younger in the Dylan McKay days, but how is it that we blinked and he’s suddenly 44?)

Take a look at “¡Happy Birthday Guadalupe!”—and Luke Perry with a dusty cowboy hat—after the jump.

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